Journal Information
Journal ID (publisher-id): BM
Journal ID (nlm-ta): Biochem Med (Zagreb)
Title: Biochemia Medica
Abbreviated Title: Biochem. Med. (Zagreb)
ISSN (print): 1330-0962
ISSN (electronic): 1846-7482
Publisher: Croatian Society of Medical Biochemistry and Laboratory Medicine
Article Information
Copyright statement: ©Croatian Society of Medical Biochemistry and Laboratory Medicine.
Copyright: 2023, Croatian Society of Medical Biochemistry
License (open-access):
This is an Open Access article distributed under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Date received: 18 May 2023
Date accepted: 11 July 2023
Publication date (print and electronic): 15 October 2023
Volume: 33
Issue: 3
Electronic Location Identifier: 030702
Publisher ID: bm-33-3-030702
DOI: 10.11613/BM.2023.030702
Association of smoking cigarettes, age, and sex with serum concentrations of olanzapine in patients with schizophrenia
Mate Kadija[1]
Andrijana Ščavničar[2]
Maja Živković[3]
[1] Faculty of pharmacy and biochemistry, University of Zagreb, Zagreb, Croatia
[2] Department of laboratory diagnostics, University hospital centre Zagreb, Zagreb, Croatia
[3] Clinic for psychiatry, Clinical hospital Vrapče, Zagreb, Croatia
[4] Department of psychiatry and psychological medicine, University hospital centre Zagreb, Zagreb, Croatia
[5] School of medicine, University of Zagreb, Zagreb, Croatia
Author notes:
[*] Corresponding author: miha_1808@hotmail.com
Introduction
Olanzapine is an atypical antipsychotic drug which is effective in the treatment of schizophrenia. Cigarette smoking, age, and sex could be related to the pharmacokinetics and serum concentrations of olanzapine in patients with schizophrenia. The aim of the study was to examine whether there was a significant difference in the serum olanzapine concentrations with regard to the mentioned factors.
Materials and methods
A total of 58 outpatients with schizophrenia (37 smokers, 42 men, 35 older than 40 years) participated in the study. Blood was sampled in serum tubes just before taking the next dose of olanzapine. Olanzapine was extracted by liquid-liquid extraction and was measured by an in-house high-performance liquid chromatography method on Shimadzu Prominence HPLC System with diode array detector SPD-M20A (Shimadzu, Kyoto, Japan). The results were expressed as the ratio of concentration to the daily dose of olanzapine (C/D). Non-parametric statistical tests were used to analyse differences between variables.
Results
The median C/D of olanzapine (interquartile range) in smokers was 6.0 (3.4-10.2) nmol/L/mg and in non-smokers 10.1 (5.9-17.6) nmol/L/mg; P = 0.007. The median C/D of olanzapine in patients younger than 40 years was 5.6 (4.5-10.2) nmol/L/mg and in patients older than 40 years 8.4 (5.6-13.0) nmol/L/mg; P = 0.105. The median C/D of olanzapine in male patients was 6.6 (4.6-10.4) nmol/L/mg and in female patients 9.0 (5.9-15.3) nmol/L/mg; P = 0.064.
Keywords: central nervous system diseases; olanzapine; smoking; therapeutic drug monitoring
