Journal Information
Journal ID (publisher-id): BM
Journal ID (nlm-ta): Biochem Med (Zagreb)
Title: Biochemia Medica
Abbreviated Title: Biochem. Med. (Zagreb)
ISSN (print): 1330-0962
ISSN (electronic): 1846-7482
Publisher: Croatian Society of Medical Biochemistry and Laboratory Medicine
Article Information
Copyright statement: ©Croatian Society of Medical Biochemistry and Laboratory Medicine.
Copyright: 2023, Croatian Society of Medical Biochemistry
License (open-access):
This is an Open Access article distributed under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Date received: 07 March 2023
Date accepted: 19 June 2023
Publication date (electronic): 05 August 2023
Publication date (print): 15 October 2023
Volume: 33
Issue: 3
Electronic Location Identifier: 030503
Publisher ID: bm-33-3-030503
DOI: 10.11613/BM.2023.030503
Carbohydrate sulfotransferases: a review of emerging diagnostic and prognostic applications
Gramos Begolli[1]
[1] Clinic of medical biochemistry, University clinical center of Kosovo, Prishtina, Kosovo
[2] Clinical institute of laboratory diagnostics, University hospital centre Osijek, Osijek, Croatia
[3] Faculty of medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
[4] Laboratory for advanced genomics, Ruđer Bošković Institute, Zagreb, Croatia
[5] Faculty for dental medicine and health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Author notes:
[*] Corresponding author: zeljko.debeljak@gmail.com
Carbohydrate sulfotransferases (CHST) catalyse the biosynthesis of proteoglycans that enable physical interactions and signalling between different neighbouring cells in physiological and pathological states. The study aim was to provide an overview of emerging diagnostic and prognostic applications of CHST. PubMed database search was conducted using the keywords “carbohydrate sulfotransferase” together with appropriate inclusion and exclusion criteria, whereby 41 publications were selected. Additionally, 40 records on CHST genetic and biochemical properties were hand-picked from UniProt, GeneCards, InterPro, and neXtProt databases. Carbohydrate sulfotransferases have been applied mainly in diagnostics of connective tissue disorders, cancer and inflammations. The lack of CHST activity was found in congenital connective tissue disorders while CHST overexpression was detected in different malignancies. Mutations of CHST3 gene cause skeletal dysplasia, chondrodysplasia, and autosomal recessive multiple joint dislocations while increased tissue expression of CHST11, CHST12 and CHST15 is an unfavourable prognostic factor in ovarian cancer, glioblastoma and pancreatic cancer, respectively. Recently, CHST11 and CHST15 overexpression in the vascular smooth muscle cells was linked to the severe lung pathology in COVID-19 patients. Promising CHST diagnostic and prognostic applications have been described but larger clinical studies and robust analytical procedures are required for the more reliable diagnostic performance estimations.
Keywords: cancer; carbohydrate sulfotransferases; connective tissue; inflammation; tumour markers
