Journal Information
Journal ID (publisher-id): BM
Journal ID (nlm-ta): Biochem Med (Zagreb)
Title: Biochemia Medica
Abbreviated Title: Biochem. Med. (Zagreb)
ISSN (print): 1330-0962
ISSN (electronic): 1846-7482
Publisher: Croatian Society of Medical Biochemistry and Laboratory Medicine
Article Information
Copyright statement: ©Croatian Society of Medical Biochemistry and Laboratory Medicine.
Copyright: 2020, Croatian Society of Medical Biochemistry
License (open-access):
This is an Open Access article distributed under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Date received: 18 June 2020
Date accepted: 13 October 2020
Publication date (electronic): 15 December 2020
Publication date (print): 15 February 2021
Volume: 31
Issue: 1
Electronic Location Identifier: 010707
Publisher ID: bm-31-1-010707
DOI: 10.11613/BM.2021.010707
Antipsychotics-induced hyperprolactinemia and screening for macroprolactin
Ana Bakliza[1]
Katarina Matic[3]
[1] Department of Laboratory Diagnostics, Psychiatric Hospital “Sveti Ivan“ Zagreb, Croatia
[2] Faculty of Dental Medicine and Health, “Josip Juraj Strossmayer” University of Osijek, Osijek, Croatia
[3] Department of Integrative Psychiatry, Psychiatric Hospital ‘Sveti Ivan’ Zagreb, Croatia
[4] School of Medicine, University of Zagreb, Zagreb, Croatia
Author notes:
[*] Corresponding author: nedjeljka.ruljancic@pbsvi.hr
Introduction
High prolactin (PRL) concentrations are found in laboratory test results of patients on majority of antipsychotic drugs. Prevalence rates and degrees of severity of hyperprolactinemia (HPRL) based on PRL concentration may depend on the presence of macroprolactin in the serum. The aim of the study was to investigate the difference between PRL concentrations before and after precipitation of macroprolactin and to examine if there were any changes in the categorization of HPRL between samples prior and after precipitation.
Materials and methods
Total of 98 female patients (median age 33; range 19-47 years) diagnosed with a psychotic disorder, proscribed antipsychotic drugs, and with HPRL were included. Total PRL concentration and PRL concentration after macroprolactin precipitation with polyethylene glycol (postPEG-PRL) were determined by the chemiluminometric method on the Beckman Coulter Access2 analyser.
Results
Total PRL concentrations (median 1471; IQC: 1064-2016 mlU/L) and postPEG-PRL concentrations (median 1453; IQC: 979-1955 mlU/L) were significantly correlated using intraclass correlation coefficient for single measurements (mean estimation 0.96; 95%CI 0.93-0.97) and average measurement (mean estimation 0.98; 95%CI 0.96-0.99), and all investigated female patient had HPRL according to PRL and postPEG-PRL concentration. The median PRL recovery following PEG precipitation was 95; IQC: 90-100%. There was substantial agreement (kappa test = 0.859, 95% CI: 0.764-0.953) between the categories of HPRL severity based on total PRL concentrations and postPEG-PRL concentrations.
Keywords: biochemistry; hyperprolactinemia; macroprolactin; prolactin
